Gene Editing Services for Fermentation Strains

The basis for the development of modern animal husbandry is the development of the feed and fertilizer industry. Then it is necessary to eliminate the abuse of antibiotics and other drug additives, to ensure the safety of feed and fertilizer while reducing the occurrence of animal and plant diseases. In addition, it is necessary to eliminate the adverse effects of antinutritional factors on animal production and improve feed utilization in feed production.

Various microorganisms in separate media

Therefore, to meet the demand of the feed and fertilizer industry for new feed and fertilizer products that are antibiotic-free, green, safe, environmentally friendly, and efficient, Lifeasible not only provides customers with microbial fermentation services for feed and fertilizer but also genetically improves the strains commonly used in the fermentation process. We aim to provide our customers with high-quality, stable, and efficient strains for feed and fertilizer production to improve the efficiency of fermentation and other production processes.

Production strains that can be genetically edited

Lifeasible has been providing genome editing services for microorganisms used in fermentation for many years. For lactic acid bacteria, we can mainly provide you with the traditional λRed homologous recombination method and CRISPR/Cas9 technology to achieve highly accurate and efficient scar-free genome editing. Ultimately you can apply the improved strains in the field of feed and fertilizer fermentation to improve the traits and quality of your products.

Lifeasible provides technical services to genetically engineer Pichia pastoris to meet the needs of the feed and fertilizer markets for the We not only establish new metabolic pathways to enable strains to produce heterologous metabolites. We are also able to adjust the metabolic flux of the strains or delete some metabolic pathways, thus improving the production of homologous proteins or homologous metabolites. Making it better for specific feed and fertilizer fermentation processes.

To achieve maximum productivity in production such as feed and fertilizer fermentation, Lifeasible can improve and streamline the genome of Bacillus subtilis using gene knockout, knock-in, and point mutation to obtain the optimal strain. We offer optimization strategies designed to maximize the production of target products while maintaining the growth of the strain itself by knocking out non-essential and redundant genes without significantly affecting the growth state of the strain. We can provide our customers with easy-to-use Bacillus subtilis that are free of resistance markers, with high transformation efficiency and high secretion capacity.

Lifeasible provides Bacillus licheniformis genome editing services to meet customers' needs for high-quality production strains. We can provide customized Bacillus licheniformis genome improvement services, including stress-resistant strains, fast-growing strains, strains with high fermentation broth biomass, strains with antibacterial activity, and biosafety strains with high acetyl methyl methanol production, and strains with high esterase production.

To meet the demand for high-quality strains for feed and fertilizer supplementation and fermentation, Lifeasible offers Saccharomyces cerevisiae target locus-specific modification technology. We can construct special production strains including strains with low sucrose consumption, high isoprene production strains, strains with high mevalonate production, strains with high ethanol production, strains with good tolerance to harsh fermentation conditions, and strains with low cell wall stability to facilitate the release of active substances.

Lifeasible offers microbial gene-editing services for fermentation, which not only provides customers with high-quality strains to produce new green bio-feeds that are easily digested, absorbed, and utilized by animals. Moreover, our improved strains are highly stable, well-tolerated and safe, non-toxic, and can be used directly as feed and fertilizer additives. If you are interested in the services we provide or have any questions, please feel free to contact us.

For research use only, not intended for any clinical use.
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